Tag Archives: Stem Cells

Six Month Update on the Stem Cells

Diseases and conditions where stem cell treatm...
Diseases and conditions where stem cell treatment is promising or emerging. Bone marrow transplantation is, as of 2009, the only established use of stem cells.                                                 (Photo credit: Wikipedia)

As many of you know I had a stem cell implant in January at StemGenex in La Jolla California.  I had been somewhat discouraged by the effect on my Parkinson’s disease but two different people in the past week have spontaneously remarked that my tremors have reduced. The tremors have spread to the other side, but are less intense.  So it may well be that I am not the best judge- I only pay attention when the tremors are active.

I want to say right off that even if I’d had no effects whatsoever from the stem cell implant that valuable information would be derived from the study.  We need to learn who responds and who does not.  There are considerations of the effects on insulin resistance and gut bacteria, as well as vagus nerve stimulation that affect the success of stem cell implants. We need more experimentation on how and where to administer the cells and what activities will impact their proliferation.  (Too bad for nonresponding participants who pay out of pocket but good for science.)

It is true that I haven’t had the dramatic changes that I expected. And I might have done better with stem cells taken from the cord blood of a newborn rather than my own adipose (fat) cells. When you are fat, the fat cells can be hypoxic and less vital. One doctor I spoke with in Mexico said he prefers cord blood because the stem cells are more active, even if there are considerably fewer of them.  If you are heavy and are considering stem cell implants you might consider using cord blood.  Cord blood is not available in the US, but there are reputable firms outside of the country.

Do I think losing weight prior to a stem cell implant might have helped?  Only with a few years lead time and lots of detoxification.  The problem is that fat stores toxins to protect the body from the harm they can cause.  I have tested high for lead, strontium, DDE and other endocrine-disrupting compounds. Weight loss can dump toxins into the blood stream and tissues as fat cells are broken down or deflated, which is why I have gotten sick every single time I lost weight, even slowly.  I did a course of herbal detox  and DMPS, EDTA, and Olestra (1) chelation prior to the stem cell implant to reduce toxins but stopped a month before the implant to let my body normalize.  Chelation cannot be done after the implant until the cells have finished multiplying.

A friend tells me that our neighbor is still experiencing improvements 2 years after his stem cell implant – and it took a while to build up.  He saw the greatest improvement after he started getting deep massage and using a vibration platform late in the first year. So there is still hope. It has been only 6 months. One woman with MS who was going through the implant with me for the third time said that the first time there was no change until 6 months and suddenly she was able to raise her legs two feet instead of two inches.  Pazienza, Karen!

Confidence Fitness Vibration Platform. http://amzn.to/1Ge8Ifw
Confidence Fitness Vibration Platform. At http://amzn.to/1Ge8Ifw

I was advised by a colleague with Parkinson’s to get a vibration platform to increase the stem cell activation and to reduce Parkinson’s symptoms. I used one last week while visiting my parents and it definitely activates qi and blood, affecting not only circulation but eliciting a strong stretch-reflex contraction in muscle fibers.  It is a very efficient anaerobic form of resistance training and they claim that 10 minutes of platform exercise is like 60 minutes of regular exercise.  Vibration platforms for the home run between $200- $6000.  While the pure platforms without handholds look like they give a stronger vibration and certainly fit better in a NYC apartment, the design looks risky for someone with Parkinson’s.  The $250 Confidence Fitness machine has over 700 five star reviews on Amazon.  I am saving up for it now.

Handhold- less dual motor vibration plate (what do you do with the remote while shaking?
Handhold- less dual motor vibration plate (what do you do with the remote while shaking?)
  1. Ronald J. Jandacek, James E. Heubi, Donna D. Buckley, Jane C. Khoury, Wayman E. Turner, Andreas Sjödin, James R. Olson, Christie Shelton, Kim Helms, Tina D. Bailey, Shirley Carter, Patrick Tso, Marian Pavuk.Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. The Journal of Nutritional Biochemistry, 2014; 25 (4): 483 DOI: 10.1016/j.jnutbio.2014.01.002

 

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How Long Does it Take After a Stem Cell Implant to See Results?

Diseases and conditions where stem cell treatm...
Diseases and conditions where stem cell treatment is promising or emerging. (See Wikipedia:Stem cell#Treatments). Bone marrow transplantation is, as of 2009, the only established use of stem cells. Model: Mikael Häggström. To discuss image, please see Template talk:Häggström diagrams (Photo credit: Wikipedia)

How long does it take before I will see the results of the stem cells? The short answer is that it varies considerably, as stem cell proliferation and concentration increases.

One woman in my group was so pleased with the turnaround in her  30 year MS that she came back for more, In her first treatment she had absolutely no improvement for 6 months, when all of a sudden she could raise her leg two feet instead of two inches. She subsequently went from not being able to turn over in bed to being able to drive herself to the gym and work out and she has retained her improvements for several years. But she went through the treatment with another woman with longstanding MS whose improvements mostly happened the first month.

So far my improvements are subtle. My foot spasms which have interfered with exercise are significantly reduced, I am told that I look livelier. My win rate at Solitaire (hand and mind) is up 5 points. And my blood sugar is somewhat reduced.  After three months I will have my blood retested and after 6, my vision evaluated. My stamina is notably improved:

(The first day of hyperbaric treatment in Great Neck I was let out of the bus at the bottom of a steep hill with no center in sight. I phoned and they told me to walk up the hill and turn left. That left me in the LIJ hospital parking lot where I questioned a guard only to find that that I had climbed the wrong hill and needed to walk back down again and climb an even steeper hill. It would be fair to say I couldn’t have done that before.)

You can’t smoke anything:  a single cigarette or joint during the initial month can knock out the new proliferating cells.  And you can’t drink at all for 9 months.  They told us of a COPD client who went on a $15,000 bender,wiping out all of his progress.  We are to eat a whole food diet high in flavanoids.  I have added huperizia and vinoceptine supplements to oxygenate my brain and wear my SomaPulse electromagnetic frequency pulse generator which was designed to proliferate stem cells.

I am still fundraising. I have 40 sessions of hyperbaric oxygen at $200-$250 a pop and they need to be done together, which cuts into my income, I have a Groupon for the first 5, but after that I don’t have the money. This is necessary to cause the stem cells to proliferate.

I am including a link to a tremendous story on stem cells helping a stroke victim, former Redwings hockey player Gordie Howe. This is from a different company, Stemedica Cell Technologies of San Diego, and they injected the cells directly into the spinal fluid which had to take place in Mexico. He got up and walked at once. http://blogs.windsorstar.com/…/howe-makes-phenomenal-recove… Let’s hope this technique gets approved here!

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Getting Through the Blood Brain Barrier

BBB and nose limbic systemPeople have been asking how the stem cells go past the blood brain barrier to get to the substantia nigra where dopamine is made. Stem cells are not supposed to be able to cross the BBB, which is why early stem cell treatment for Parkinson’s was not broadly successful.But it seems that the Blood Brain Barrier is less a barrier than a regulator which can at times be selective in what it lets through.Now it isn’t clear to me whether the stem cells actually go through the BBB or just signal cells on the other side but it does appear to make a significant difference clinically.  I think they do get through based on the research cited below.

 There are three primary sorts of barriers of the BBB, the vascular brain barrier, blood-CSF barrier, and the specialty CNS barriers such as the blood-retinal barrier.  They transport molecules in by pores, the opening of tight junctions and receptors. (1) One can also bypass the BBB by going through the nose or injecting directly into the cerebral spinal fluid. This even works for larger molecules like peptides and other proteins.(1) Injecting insulin through the nose has been helpful for Alzheimer’s for instance. And they injected stem cells into the middle turbinate of my nose as one form of administration. It was weird but topical lidocaine prevented pain.

BBB and junctions
Ways through the Blood Brain Barrier

However researchers also found that mannose IV infusions open pores in the BBB and increase enzyme passage 10 fold (2). In fact mannose infusion has become a standalone therapy as well as a way of getting drugs to the brain.

StemGenex, the center that performed my stem cell administration, started using mannose infusions long before they started using intranasal injection. It increased the success for neurological conditions. Their mannose solution increases the diameter of pores for 20 minutes, so it is immediately followed by injected and IV stem cell administration.

English: The Blood Brain Barrier and Astrocyte...
English: The Blood Brain Barrier and Astrocytes type 1 (Photo credit: Wikipedia)

If you are academically inclined, the following articles give the science behind getting through the BBB. Our understanding of the BBB is growing every day.

 

 

And if you would be so kind as to help fund my Parkinson’s stem cell transplant: http://www.gofundme.com/eg4ymk

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